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1.1 Reagents

APPENDIX 1 GENERAL INFORMATION

                The specifications given below are strictly for the use of the materials as reagents. The inclusion of a material in this Appendix does not imply that it is suitable for use in medicines. Exceptionally, a trademark or supplier may be indicated for certain reagents whose availability is limited. It is however acceptable to use reagents from another source provided that they comply with the standards of the Pharmacopoeia.

1.1 REAGENTS

                The name of a substance or solution indicates a reagent included in the following list. The specifications given for reagents do not necessarily guarantee their quality for use in medicines.

                Some of the reagents included may be injurious to health. Important cautions have been stated for these reagents. They should be handled in accordance with good laboratory practice and any relevant regulations. Reagents in aqueous solution are prepared using water. Where the name of the solvent is not stated, an aqueous solution is intended.

                Unless otherwise specified, the reagents and reagent solutions are to be stored in well containers. The labelling should comply with the relevant national legislation.

Alanine C3H7NO2 = 89.09

Use an analytical reagent grade of commerce containing not less than 98.0 per cent w/w of C3H7NO2.

DESCRIPTION  White, crystalline powder; odourless.

SOLUBILITY  Freely soluble in water; slightly soluble in ethanol.

MELTING TEMPERATURE  About 297°, with decomposition (Appendix 4.3).

Store in tightly closed containers.

Aluminium Chloride, Anhydrous AlCl3 = 133.34

DESCRIPTION  White, crystalline powder; odour, strong of hydrogen chloride.

SOLUBILITY  Freely soluble in many organic solvents such as benzophenone, nitrobenzene; soluble in benzene, in carbon tetrachloride, and in chloroform.

MELTING TEMPERATURE  About 193º (Appendix 4.3).

Store in tightly closed containers, protected from moisture.

Betulinic Acid C30H48O3 = 456.70

DESCRIPTION  White, crystalline powder.

MELTING RANGE  316° to 318° (Appendix 4.3).

Store in tightly closed containers.

Blumeatin C16H14O= 302.28

Use an analytical reagent grade of commerce containing not less than 95.0 per cent w/w of C17H14O6.

DESCRIPTION  Yellow, crystalline powder.

SOLUBILITY  Soluble in dimethyl sulfoxide.

Store in tightly closed containers.

Hesperidin C28H34O15 = 610.56

DESCRIPTION  Light brown, crystalline powder.

MELTING RANGE  250º to 255° (Appendix 4.3).

Store in tightly closed containers.

Luteolin C15H10O6 = 286.24

Use an analytical reagent grade of commerce containing not less than 98.0 per cent w/w of C15H10O6.

DESCRIPTION  Yellow, crystalline powder.

MELTING TEMPERATURE  About 330° (Appendix 4.3).

Store in tightly closed containers at a temperature between 2° and 8°, protected from light.

α-Mangostin C24H26O= 410.46

Use an analytical reagent grade of commerce containing not less than 98.0 per cent w/w of C24H26O6.

DESCRIPTION  Yellow, crystalline solid.

SOLUBILITY  Soluble in methanol.

MELTING TEMPERATURE  About 182° (Appendix 4.3).

Store in tightly closed containers at a temperature between 4° and 8°.

Naringin C27H32O14 = 580.53

Use an analytical reagent grade of commerce containing not less than 95.0 per cent w/w of C27H32O14.

DESCRIPTION  Light brown, crystalline powder.

SOLUBILITY  Slightly soluble in water.

MELTING TEMPERATURE  About 83° (Appendix 4.3).

Store in tightly closed containers.

Terpinen-4-ol C10H18O = 154.25

Use an analytical reagent grade of commerce containing not less than 95.0 per cent w/w of C10H18O.

DESCRIPTION  Colourless to pale yellow, oily liquid.

SOLUBILITY  Soluble in oils; slightly soluble in water.

BOILING TEMPERATURE  About 209° (Appendix 4.6).

Store in tightly closed containers, protected from light, and at a temperature between 2° and 8°.

THP 2021 Supplement 2025 • 1.1 Reagents
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