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7.3H DETERMINATION OF VOLATILE OIL

          Carry out the determination according to the nature of the drug to be examined. Place the prescribed quantity of the drug in the round-bottomed flask of suitable capacity as specified in the monograph and add the prescribed volume of distillation liquid. Set up the apparatus (Fig.1), inserting a reflux condenser (Fig.2). Fill the graduated tube with water to the standard line and add the prescribed volume of xylene. Heat the liquid in the flask in an oil-bath between 130° and 150° to boiling and adjust the distillation rate as prescribed in the monograph. Unless otherwise specified, continue boiling for 5 hours at the same rate. Allow it to stand for some time, open the stopper of the apparatus and draw off the water slowly until the level of the xylene and volatile oil mixture corresponds to the preparation line, and allow it to stand for more than 1 hour at cool temperature. Then lower the level of the xylene and volatile oil mixture to the zero line, and read the volume in millilitre of the mixture of xylene and volatile oil at cool temperature. Subtract the volume in millilitre of xylene from the volume of the mixture of xylene and volatile oil and calculate the percentage of volatile oil content in the sample.

 

APPENDICES • 7.3H DETERMINATION OF VOLATILE OIL
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หมายเหตุ / Note : THP 2021 Page 924-925